Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389352401> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2389352401 endingPage "8" @default.
- W2389352401 startingPage "93" @default.
- W2389352401 abstract "By using R-banding karyotypic analysis technique, the bone marrow (BM) cells were performed in 223 hematopoietic malignacies and 105 diopathic throbocytopenic purpura (ITP), which served as control. The following results were obtained: (1) Nonrandom chromosome loss (NCL), such as, -11, -14, -21, etc, which were found in the affected members of leukemia families, were found in about 30% sporadic ANLL, MDS and about 50% ALL, espedislly in 100% (5/5) CLL, but not found in ITP (P < 0.001). These results indicated that the familial nonrandom chromosome loss were associated with leukomogenesis. (2) Because most of BM cells are hypodiploed and have the same kinds of NCL in each cases of CLL, which can develop into ALL, ANLL and also cancers, ALL BM hypo- and hyper-diploid and/or polyploid cells might be origin of hypodiploid cells. (3) 28% (6/21) of pediatric patients with AL, MDS, or FA (Fanconi Anemia) have one parent, who have up to 30% BM hypodiploid cells and similar kinds of NCL and also have the rearrangement of C-erbB and abnormal proliferation of BM. The NCL were found in the three consecutive generations of a family with 5 ALL among 10 members of third generation. It indicated that the familial NCL might be inherited and be coded by a unknown gene alteration, which might be related to leukomo and carcinogenesis, because there are genes or their candidates for leukemia in the chromosomes 11, 14 and 21. (4) Based on the works of my colleages and I, the model of leukomo and carcinogenesis was proposed and the relationship between chromosome monosomy, deletion, translocations and leukomogenesis were showed elswhere. The significance of monosomy 11, 14 and 21 etc. were discussed briefly." @default.
- W2389352401 created "2016-06-24" @default.
- W2389352401 creator A5010210315 @default.
- W2389352401 creator A5043621886 @default.
- W2389352401 creator A5064330752 @default.
- W2389352401 creator A5065867115 @default.
- W2389352401 creator A5081782818 @default.
- W2389352401 date "1999-01-01" @default.
- W2389352401 modified "2023-09-23" @default.
- W2389352401 title "[Relationship between the familial nonrandom chromosome loss (NCL) and leukomogenesis]." @default.
- W2389352401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10375857" @default.
- W2389352401 hasPublicationYear "1999" @default.
- W2389352401 type Work @default.
- W2389352401 sameAs 2389352401 @default.
- W2389352401 citedByCount "0" @default.
- W2389352401 crossrefType "journal-article" @default.
- W2389352401 hasAuthorship W2389352401A5010210315 @default.
- W2389352401 hasAuthorship W2389352401A5043621886 @default.
- W2389352401 hasAuthorship W2389352401A5064330752 @default.
- W2389352401 hasAuthorship W2389352401A5065867115 @default.
- W2389352401 hasAuthorship W2389352401A5081782818 @default.
- W2389352401 hasConcept C104317684 @default.
- W2389352401 hasConcept C109159458 @default.
- W2389352401 hasConcept C134935766 @default.
- W2389352401 hasConcept C143191323 @default.
- W2389352401 hasConcept C153911025 @default.
- W2389352401 hasConcept C174475383 @default.
- W2389352401 hasConcept C203014093 @default.
- W2389352401 hasConcept C2778124228 @default.
- W2389352401 hasConcept C2778461978 @default.
- W2389352401 hasConcept C2780007613 @default.
- W2389352401 hasConcept C28328180 @default.
- W2389352401 hasConcept C30481170 @default.
- W2389352401 hasConcept C502942594 @default.
- W2389352401 hasConcept C53226629 @default.
- W2389352401 hasConcept C54355233 @default.
- W2389352401 hasConcept C555283112 @default.
- W2389352401 hasConcept C86803240 @default.
- W2389352401 hasConceptScore W2389352401C104317684 @default.
- W2389352401 hasConceptScore W2389352401C109159458 @default.
- W2389352401 hasConceptScore W2389352401C134935766 @default.
- W2389352401 hasConceptScore W2389352401C143191323 @default.
- W2389352401 hasConceptScore W2389352401C153911025 @default.
- W2389352401 hasConceptScore W2389352401C174475383 @default.
- W2389352401 hasConceptScore W2389352401C203014093 @default.
- W2389352401 hasConceptScore W2389352401C2778124228 @default.
- W2389352401 hasConceptScore W2389352401C2778461978 @default.
- W2389352401 hasConceptScore W2389352401C2780007613 @default.
- W2389352401 hasConceptScore W2389352401C28328180 @default.
- W2389352401 hasConceptScore W2389352401C30481170 @default.
- W2389352401 hasConceptScore W2389352401C502942594 @default.
- W2389352401 hasConceptScore W2389352401C53226629 @default.
- W2389352401 hasConceptScore W2389352401C54355233 @default.
- W2389352401 hasConceptScore W2389352401C555283112 @default.
- W2389352401 hasConceptScore W2389352401C86803240 @default.
- W2389352401 hasIssue "2" @default.
- W2389352401 hasLocation W23893524011 @default.
- W2389352401 hasOpenAccess W2389352401 @default.
- W2389352401 hasPrimaryLocation W23893524011 @default.
- W2389352401 hasRelatedWork W1970446973 @default.
- W2389352401 hasRelatedWork W1980928865 @default.
- W2389352401 hasRelatedWork W2023315550 @default.
- W2389352401 hasRelatedWork W2024689105 @default.
- W2389352401 hasRelatedWork W2029806801 @default.
- W2389352401 hasRelatedWork W2061579975 @default.
- W2389352401 hasRelatedWork W2067189517 @default.
- W2389352401 hasRelatedWork W2072185359 @default.
- W2389352401 hasRelatedWork W2441931660 @default.
- W2389352401 hasRelatedWork W2897877078 @default.
- W2389352401 hasVolume "26" @default.
- W2389352401 isParatext "false" @default.
- W2389352401 isRetracted "false" @default.
- W2389352401 magId "2389352401" @default.
- W2389352401 workType "article" @default.