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- W2389354369 abstract "Objective To observe changes of insulin like growth factor Ⅱ (IGF Ⅱ) in cerebrospinal fluid (CSF) of children with infection of central nervous system (CNS) and the relations between the levels of IGF Ⅱ in CSF and the levels of glucose and protein and the white blood cell counts in CSF. Methods CSF samples were obtained from forty five patients:twenty four cases with bacterial meningitis(BM)and twenty one cases with viral encephalitis(VM). CSF control samples were obtained from fifteen children without any neurologic diseases. The levels of IGF Ⅱ were determined by immunoradiometricassay (IRMA). Results 1. The evels of IGF Ⅱ were markedly higher in the CSF of patients with BM 64.56±49.61 ng/ml than patients with VE 31.41±7.16 ng/ml ( P 0.01) and control group 27.19 ±6.85 ng/ml ( P 0.01). 2. The levels of CSF IGF Ⅱ of children with CNS infection negatively correlated with the levels of CSF glucose ( r =-0.561 P 0.01), but positively correlated with the concentrations of protein in CSF ( r =0.839 P 0.001) .Conclusions 1. The change of IGF Ⅱ in CSF in children with CNS infection indicate that they may participate in pathophysiological mechanisms of CNS infection. 2. IGF Ⅱ may participate in the mechanism of changes of CSF glucose and protein levels in CSF in children with CNS infection. 3. Testing the levels of IGF Ⅱ may be valuable in diagnosis of BM and VE." @default.
- W2389354369 created "2016-06-24" @default.
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- W2389354369 date "2003-01-01" @default.
- W2389354369 modified "2023-09-27" @default.
- W2389354369 title "Changes of insulin-like growth factor-II in cerebrospinal fluid in children with infection of the central nervous system" @default.
- W2389354369 hasPublicationYear "2003" @default.
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