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- W2389385487 abstract "In certain conditions,lysosomal membrane permeabilization could be induced by a broad array of stimuli including reactive oxygen species(ROS),sphingosine,and some endogenous cell death effector proteins such as Bax.As a consequence of LMP,lysosomal proteases(such as cathepsins) and other hydrolases were released from the lysosomal lumen to the cytosol,where they lead to apoptosis by the activation apoptotic cascades.This review describes the possible molecular mechanisms underlying the occurrence of lysosomal membrane permeabilization and the consequent lysosome-mediated apoptosis." @default.
- W2389385487 created "2016-06-24" @default.
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- W2389385487 date "2011-01-01" @default.
- W2389385487 modified "2023-09-23" @default.
- W2389385487 title "Lysosomes and apoptosis" @default.
- W2389385487 hasPublicationYear "2011" @default.
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