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- W2389403506 abstract "Objective To observe the expression of vascular endothelial growth factor(VEGF),factor Ⅷ related antigen(FⅧ R Ag) in rat brain tissue in the border zone of the hematoma,and to explore the relationship between the expression of VEGF and the brain angiogenesis after intracerebral hemorrhage (ICH).Methods Rat model of ICH was established by injection of physiological saline containing collagenase into the right caudate nucleus.The immunohistochemical methods were used to examine expression of VEGF and FⅧ R Ag in rat brain at 12 h,1 d,3 d and 7 d after ICH,respectively.Results The amount of VEGF positive cells was markedly increased and reached the highest on d 7 in the border zone after ICH (P0.01),but there was no significant difference between the mean values of A (absorbance) of cells at different time points (P0.05).Compared with the controls,both the FⅧ R Ag positive endothelial cells and the A of cells were significantly different in experimental ICH groups after 1 d.Conclusion The upregulated expression of VEGF might induce proliferation of endothelial cells and angiogenesis in the border zone after ICH in rats." @default.
- W2389403506 created "2016-06-24" @default.
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- W2389403506 date "2003-01-01" @default.
- W2389403506 modified "2023-09-26" @default.
- W2389403506 title "The expression of VEGF and FVIII-R Ag in the border zone of hematoma after intracerebral hemorrhage in rats" @default.
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