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- W2389422062 abstract "Objective To introduce the establishment of cortex infarct model in severe combined immunodeficiency (SCID) mouse,and a new relatively quantitative analysis method for infarct volume ~explored. Methods Left middle cerebral arteries of SCID mice were occluded and cut by a bipolar ~electrocoagulator at the site 1~2mm lateral middle cerebral artery from left olfactory tract under ~microscopy. One group of mice was sacrificed 24 hours later. Infarct area was evaluated by perfused transcardially with ink and stained with 2,3,5-triphenyltetrazolium (TTC).And 1 month later, whole brain images were captured using a microscopic digital camera system. The maximum width from the midpoint of the brain was measured and the ratio of left/right width was defined as the cortical width index.Results There was a high success rate of 90% with this animal model. The site of infarct was restricted at the cortex. The value of CWI was 0.34±0.03,with variety coefficient 8.8%.Conclusion The cortical infarction in SCID mice shows a character of high success rate and stabilization. The CWI can work as a convenient and reliable criterion to evaluate the cerebral ~infarction." @default.
- W2389422062 created "2016-06-24" @default.
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- W2389422062 date "2005-01-01" @default.
- W2389422062 modified "2023-09-27" @default.
- W2389422062 title "Establishing a cortical infarction model of severe combined immunodeficiency mouse" @default.
- W2389422062 hasPublicationYear "2005" @default.
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