Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389448128> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2389448128 abstract "[Objective]To study the neuroprotective effects and mechanism of curcumin on mice with cerebral ischemia and reperfusion by analyzing the changes of NO content,Bcl-2 and Bax protein.[Methods]Kunming male healthy mice(n=180) were divided into sham-operated group(group A),Solvent control group(group B),curcumin treatment group(group C) randomly.After ischemia and reperfusion,all groups were divided into 3 h,6 h,24 h,48 h and 72 h subgroups.The mouse models of focal cerebral ischemia and reperfusion were established by suture method.The neurological score of each group was estimated at 24 h.The histopathologic changes were observed by the HE staining method.The NO level wasdetected by the method of nitric acid reductase.Immunochemistry was used to evaluate the expression level of Bcl-2,Bax.[Results]The neurological score in group B was significantly higher than that of group A.While in group C it was significantly different with group B(P0.05).The content of NO was significantly different between group A and B group at 3 h,6 h and 24 h(P0.05).While there were significant differences between C group and B group at 6 h and 24 h(P0.05).The Bcl-2 and Bax expression were increased,while Bcl-2/Bax was decreased in group B.In group C,Bcl-2 expression was obviously increased,and Bax expression was reduced.[Conclusion]Curcumin has neuroprotective effect on mice with cerebral ischemia and reperfusion.Its mechanism might be that the decreasing of expression of NO content and Bax increasing results in inhibition of Bax protein expression and decreased apoptosis and then lead to reduction of delayed neuronal damage after cerebral ischemia." @default.
- W2389448128 created "2016-06-24" @default.
- W2389448128 creator A5077363225 @default.
- W2389448128 date "2012-01-01" @default.
- W2389448128 modified "2023-09-23" @default.
- W2389448128 title "Effects of curcumin on NO content and expression of Bcl-2 and Bax in brain tissue of mice with cerebral ischemia and reperfusion injury" @default.
- W2389448128 hasPublicationYear "2012" @default.
- W2389448128 type Work @default.
- W2389448128 sameAs 2389448128 @default.
- W2389448128 citedByCount "0" @default.
- W2389448128 crossrefType "journal-article" @default.
- W2389448128 hasAuthorship W2389448128A5077363225 @default.
- W2389448128 hasConcept C126322002 @default.
- W2389448128 hasConcept C159654299 @default.
- W2389448128 hasConcept C203014093 @default.
- W2389448128 hasConcept C204232928 @default.
- W2389448128 hasConcept C25498285 @default.
- W2389448128 hasConcept C2777785397 @default.
- W2389448128 hasConcept C2778250585 @default.
- W2389448128 hasConcept C2780114680 @default.
- W2389448128 hasConcept C2780659158 @default.
- W2389448128 hasConcept C2780678043 @default.
- W2389448128 hasConcept C2986936838 @default.
- W2389448128 hasConcept C42219234 @default.
- W2389448128 hasConcept C541997718 @default.
- W2389448128 hasConcept C71924100 @default.
- W2389448128 hasConcept C98274493 @default.
- W2389448128 hasConceptScore W2389448128C126322002 @default.
- W2389448128 hasConceptScore W2389448128C159654299 @default.
- W2389448128 hasConceptScore W2389448128C203014093 @default.
- W2389448128 hasConceptScore W2389448128C204232928 @default.
- W2389448128 hasConceptScore W2389448128C25498285 @default.
- W2389448128 hasConceptScore W2389448128C2777785397 @default.
- W2389448128 hasConceptScore W2389448128C2778250585 @default.
- W2389448128 hasConceptScore W2389448128C2780114680 @default.
- W2389448128 hasConceptScore W2389448128C2780659158 @default.
- W2389448128 hasConceptScore W2389448128C2780678043 @default.
- W2389448128 hasConceptScore W2389448128C2986936838 @default.
- W2389448128 hasConceptScore W2389448128C42219234 @default.
- W2389448128 hasConceptScore W2389448128C541997718 @default.
- W2389448128 hasConceptScore W2389448128C71924100 @default.
- W2389448128 hasConceptScore W2389448128C98274493 @default.
- W2389448128 hasLocation W23894481281 @default.
- W2389448128 hasOpenAccess W2389448128 @default.
- W2389448128 hasPrimaryLocation W23894481281 @default.
- W2389448128 hasRelatedWork W2417052918 @default.
- W2389448128 hasRelatedWork W2590804131 @default.
- W2389448128 hasRelatedWork W2750050969 @default.
- W2389448128 hasRelatedWork W2992707701 @default.
- W2389448128 hasRelatedWork W3022080689 @default.
- W2389448128 hasRelatedWork W3028898931 @default.
- W2389448128 hasRelatedWork W3029056795 @default.
- W2389448128 hasRelatedWork W3029653415 @default.
- W2389448128 hasRelatedWork W3029840003 @default.
- W2389448128 hasRelatedWork W3029902553 @default.
- W2389448128 hasRelatedWork W3029948411 @default.
- W2389448128 hasRelatedWork W3030399257 @default.
- W2389448128 hasRelatedWork W3031215756 @default.
- W2389448128 hasRelatedWork W3031298675 @default.
- W2389448128 hasRelatedWork W3031686988 @default.
- W2389448128 hasRelatedWork W3031709110 @default.
- W2389448128 hasRelatedWork W3031939697 @default.
- W2389448128 hasRelatedWork W3032602357 @default.
- W2389448128 hasRelatedWork W3032628502 @default.
- W2389448128 hasRelatedWork W3032641131 @default.
- W2389448128 isParatext "false" @default.
- W2389448128 isRetracted "false" @default.
- W2389448128 magId "2389448128" @default.
- W2389448128 workType "article" @default.