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- W2389460096 abstract "Objecttive To investigate the specificity of serology diagnostic testing for anti coronavirus antibody in patients with severe acute respiratory syndrome (SARS) and discuss the fasle-positive of SARS-associated coronavirus (SARS-CoV) antibody in patients with systemic lupus erythematosus(SLE) , Sjogren's syndrome (SS) , rheumatoid arthritis (RA) and mixed connective tissue disease (MCTD). Methods 111 normal controls,including 10 SS,16 MCTD,20 RA and 58 SLE with non-SARS patients were detected for anti SARS-CoV antibody and RNA by enzyme-linked immunosorbent assays ( ELISA) and reverse transcriptase-polymerase chain reaction ( RT-PCR) respectively. Results The result showed 4/111 cases (3. 6% ) were positive of SARS-CoV-IgG antibody and 111 cases were negative of SARS-CoV-IgM antibody. The specificity of both SARS-CoV-IgG and IgM antibody for was 100%. in 58 cases with SLE. The positive rates of SARS-CoV-IgG and IgM antibodies were 32. 8% (19/58) and 8. 6% (5/58) Respectively, in which 11 cases( 19% ) were positive of both SARS-CoV-IgG and IgM antibody. In 10 cases with SS, The positive rate of both SARS-CoV-IgG and IgM antibody was 10% (1/10). In 16 cases with MCTD, the positive rate of SARS-CoV-IgG was 37. 5% (6/16), the positive rate of both SARS-CoV-IgG and IgM antibodies was 6. 3% (1/16). in 20 cases with RA,one case was positive(5% ). All samples of positive SARS-CoV-IgG and IgM antibodies were negative by RT-PCR. Conclusion The results suggested that the ELISA kit coated by non-purified SARS-CoV antigen may induce the false-positive results of SARS-CoV antibody in patients with autoimmune disease. The specificity of ELISA tests for SARS was excellent and has low fasle-positive rates when using SARS-CoV-IgG and IgM antibody tests, the false-posotive results of SARS-CoV-IgG and IgM antibody may be related to coated antigens with SARS-CoV and Vero-E6 cells in patients with autoimmune disease." @default.
- W2389460096 created "2016-06-24" @default.
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- W2389460096 date "2004-01-01" @default.
- W2389460096 modified "2023-09-25" @default.
- W2389460096 title "Analysis of the false-positive results associated with antibody tests for SARS-CoV in autoimmune disease patients" @default.
- W2389460096 hasPublicationYear "2004" @default.
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