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- W2389461974 abstract "Objective To investigate the effects of pemetrexed combined with cisplatin on the proliferation and apoptosis of SW480cells.Methods The SW480cells were treated with pemetrexed(group A)or cisplatin(group B)alone or in combination(group AB).The growth,apoptosis and cell cycle of SW480 cells were examined by MTT assay and flow cytometry.The expressions of proliferating cell nuclear antigen(PCNA)and cell apoptosis-associated protein Bcl-2were detected by Western blot.Results Pemetrexed and cisplatin suppressed dose-dependently the growth of SW480cells,which was more when combined use of both drugs.The percentage of the cell cycle blocked at G1phase in group AB was(77.8±2.3)%,which was higher than(64.9±2.2)%in group A or(66.3±1.1)%in group B(P0.05).The apoptosis rate of SW480cells in group AB was(21.8±2.3)%,which was higher than(8.5±0.5)% in group A or(11.2±2.1)% in group B(P0.05).The expressions of PCNA and Bcl-2in three groups were lower after treatment than those before(P0.05).Conclusion Pemetrexed and cisplatin can inhibit cell proliferation and promote the apoptosis of SW480cells,which is better when combined use of both drugs." @default.
- W2389461974 created "2016-06-24" @default.
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- W2389461974 date "2013-01-01" @default.
- W2389461974 modified "2023-09-23" @default.
- W2389461974 title "Effects of pemetrexed combined with cisplatin on proliferation and apoptosis of human colon cancer cells" @default.
- W2389461974 hasPublicationYear "2013" @default.
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