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- W2389462016 abstract "Objective To investigate the antioxidative effects of rubidate on ischemic myocardium in mice.Methods Myocardial ischemia in mice was produced by isoproterenol(ISO).Glutathione peroxidase (GSH-Px) activity was determined by photometric method. Superoxide dismutase (SOD) activity was determined by pyrogallol auto oxidation method. Malondialdehyde (MDA) formation was detected with thiobarbituric acid(TBA).Results Pretreatment with rubidate 500 and 2 000 mg/(kg·d)×7 d protected GSH-Px and SOD activities in the hearts of ISO-treated mice. Rubidate 2 000 mg/(kg·d)×7 d diminished MDA production. However, rubidate 500 mg/(kg·d) did not show such an effect.Conclusion Rubidate inhibites lipid peroxidation expressed by malondialdehyde formation and scavenges oxygen free radicals and H 2O 2.It exhibits an antioxidative activity via scavenging free radicals." @default.
- W2389462016 created "2016-06-24" @default.
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- W2389462016 date "2004-01-01" @default.
- W2389462016 modified "2023-09-25" @default.
- W2389462016 title "Antioxidative effects of rubidate on ischemic myocardium" @default.
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