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- W2389465527 abstract "Insulin release and nitric oxide (NO) production from isolated islets of newborn Wistar rats were measured after incubation with or without cytokines. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect mRNA expression of the IL-18 receptor signaling chain (IL-18Rβ). Results showed:(1) There were no significant effects of 0.625～10 nmol/L of recombinant murine (rm) IL-18 alone on accumulated or glucose-challenged insulin release and NO production after 24 h. (2) 200 U/ml recombinant rat (rr) interferon-γ(IFN-γ) or 250 U/ml recombinant human (rh) tumor necrosis factor-α(TNF-α) had no significant effects on insulin release and NO production alone,and failed to prime islets for effects of 10 nmol/L rmIL-18 on insulin release and NO production. (3) Either 200 U/ml rrIFN-γ+250 U/ml rhTNF-α or 15 pg/ml rhIL-1β significantly increased NO production and inhibited insulin release. However,10 nmol/L rmIL-18 did not modulate the above effects caused by IFN-γ+TNF-α or IL-1β. (4) IL-18Rβ mRNA was not expressed in rat insulinoma (RIN) cells or in isolated rat islets,even after exposure to IL-1β and/or IFN-γ+TNF-α or IL-12. It concludes that IL-18 does not play a direct role in cytokine-induced islet β-cell destruction because IL-18 receptor is not expressed in islet β-cells." @default.
- W2389465527 created "2016-06-24" @default.
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- W2389465527 date "2002-01-01" @default.
- W2389465527 modified "2023-09-24" @default.
- W2389465527 title "The Role of IL-18 in Cytokine-induced Islet β-cell Damage" @default.
- W2389465527 hasPublicationYear "2002" @default.
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