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- W2389480871 abstract "AIM To study the correlation and mechanism between nitric oxide (NO) and histamine (His) regulating contraction of isolated guinea pig ileum. METHODS Guinea pig ileum segments were suspended vertically in organ baths containing oxygenated Tyrode solution maintained at 37℃, sodium nitroprusside (SNP, 15, 150, 1500 μmol·L -1 ) and SNP plus nifedipine (Nif, 25, 50, 100 nmol·L -1 ) were added, respectively, at the same time, His was added accumulatively 30 min later, His induced H 1 effect was represented by the height of the contractile curve showed on physiological recorder. RESULTS ①SNP strengthened H 1 effect induced by lower concentration of His(0.01-0.1 μmol·L -1 ), and with the increasing concentration of His, the strengthening effect of SNP became weaker. ②In Ca 2+ -free Tyrode solution, H 1 effects induced by His with or without SNP were attenuated to the same level. ③Nif concentration-dependently inhibited His induced H 1 effect mediated by SNP or not. CONCLUSION The results suggest that SNP strengthen His induced H 1 effect and it is related to extracellular Ca 2+ influx through L-type Ca 2+ channels." @default.
- W2389480871 created "2016-06-24" @default.
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- W2389480871 date "2002-01-01" @default.
- W2389480871 modified "2023-09-23" @default.
- W2389480871 title "Influence of sodium nitroprusside to histamine induced H_1 effect in guinea pig ileum" @default.
- W2389480871 hasPublicationYear "2002" @default.
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