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- W2389493612 abstract "Objective:This study is Ganoderma lucidum spores on pentylenetetrazol activation of rat hippocampal neurons bax expression changes to further explore the relationship between the action mechanism of the Ganoderma lucidum spores and epilepsy with apoptosis regulatory genes of hippocampal neural.Methods:Through the preparation of the epileptic model and RT-PCR to detect of bax expression in the normal control group,epilepsy model group and Ganoderma spore powder medication group.Results:Bax expression in epilepsy model group and Ganoderma lucidum spores medication group were higher than in the normal control group(0.17 ± 0.04);including bax expression level in epilepsy model group(0.66 ± 0.09) was significantly higher than in the control group(0.17 ± 0.04)(P0.01),bax expression level in Ganoderma spore powder medication group(0.47 ± 0.1) were significantly lower than in epilepsy model group(P0.01),the difference was statistically significant.Conclusion:The results of this study confirmed that model group and the treatment group of bax expression were significantly higher than the normal control group after PTZ kindled,it show that bax genes play a catalytic role in the regulation of apoptosis process.Bax expression were significantly lower than model group after given Ganoderma lucidum spores treatment.It point active ingredients of Ganoderma spore powder can fully act on the brain tissue and regulate the expression of bax in order to play the role of anti-apoptotic neuroprotection." @default.
- W2389493612 created "2016-06-24" @default.
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- W2389493612 date "2012-01-01" @default.
- W2389493612 modified "2023-09-25" @default.
- W2389493612 title "Study of Ganoderma lucidum spores on pentylenetetrazol activation of hippocampal neurons bax expression" @default.
- W2389493612 hasPublicationYear "2012" @default.
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