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- W2389509230 abstract "Objective To investigate the effect of Polygonum cuspidatum on hemodynamics, blood gas analysis and fibrinolysis. Methods Porcine models of hypoxic pulmonary hypertension ( n =30) were constructed. After intravenous injection of polygonum cuspidatum, the changes of indices of hemodynamics ,blood gas analysis and fibrinolysis were observed. Results The infusion of Polygonum cuspidatum caused a continuous and dramatic reduction of the mean systolic pulmonary arterial pressure( P 0.01) and increase of cardiac index ( P 0.05 ) while the systemic blood pressure, heart rate and indices of blood gas analysis remained unchanged. The drug also significantly increased the activity of tissue plasminogen activator ( P 0.01) and decreased the activity of plasminogen activator inhibitor ( P 0.05). The levels of D dimer and antithrombin Ⅲ showed no changes. Conclusion It is concluded that Polygonum cuspidatum can ameliorate the hypoxic pulmonary hypertension, increase the cardiac output, and enhance the fibrinolytic activity, but with no effect on the systemic blood pressure and oxygenation of hypoxic pigs." @default.
- W2389509230 created "2016-06-24" @default.
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- W2389509230 date "2001-01-01" @default.
- W2389509230 modified "2023-09-26" @default.
- W2389509230 title "Effectiveness of Polygonum cuspidatum on hemodynamics, blood gas analysis, and fibrinolysis" @default.
- W2389509230 hasPublicationYear "2001" @default.
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