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- W2389510452 abstract "AIM To observe the neuron apoptosis in hippocampus of dogs and the effect on the expression of related gene bcl-2 and bax during deep hypothermic circulatory arrest(DHCA) and to study the neuroprotection mechanism of intermittent selective antegrade cerebral perfusion.METHODS Eighteen healthy adult dogs(18-22 kg) were randomly divided into three groups(6 dogs in each group).The dogs in group A,B and C respectively received common temperature cardiopulmonary bypass,DHCA and intermittent selective antegrade cerebral perfusion during DHCA.After operation the hippocampus was removed immediately.Immunohistochemistry assay was used to observe the changes of the expression of bcl-2 and bax.The morphology of the hippocampal neurons was examined by transmission electron microscopy(TEM).RESULTS The level of bax expression in group B was higher than that in group A or C(P0.01).The level of bcl-2 expression in group C was higher than that in group A or B(P(0.01)).CONCLUSION The increased expression of bax may promote the neuron apoptosis during DHCA.Intermittent selective antegrade cerebral perfusion may up-regulate bcl-2 and down-regulate bax during DHCA,which inhibits the neuron apoptosis." @default.
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- W2389510452 date "2006-01-01" @default.
- W2389510452 modified "2023-09-28" @default.
- W2389510452 title "Experimental study of neuron apoptosis in hippocampus and neuroprotection during deep hypothermic circulatory arrest in dogs" @default.
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