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- W2389533844 abstract "Objective: To observe the effect of Calcium channel's blocks on Ca 2+ influx of platelets from essential hypertension. And to explore its effect on the ROC(Receptor-dependent Ca 2+ channels) of platelets. Methods Fura-2 fluorescent technique was applied to detect cell [Ca 2+ ]i, and the effects of two types of Calcium channel's blocks on Ca 2+ influx of human platelets induced by CPA differently was observed. Results The resting [Ca 2+ ]i and Ca 2+ influx of platelet in essential hypertension group is higher than that in normal group. Nifedipine can not affect the Ca 2+ influx of platelets from essential hypertension or normal induced by CPA. 5,10 or 20 μmol/L 2A-1-1(purified component from Panax notoginsengs saponins)can refrain the Ca 2+ influx of platelets from essential hypertension induced by CPA. Conclusions 2A-1-1 can block the ROC(Receptor-dependent Ca 2+ channels) of the human platelets from essential hypertension,and can refrain Ca 2+ influx of platelets." @default.
- W2389533844 created "2016-06-24" @default.
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- W2389533844 date "2005-01-01" @default.
- W2389533844 modified "2023-09-25" @default.
- W2389533844 title "Effects of 2A-1-1 on the Ca~(2+) Influx of Platelets From Essential Hypertension" @default.
- W2389533844 hasPublicationYear "2005" @default.
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