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- W2389545598 abstract "Objective To explore the association between polymorphism of urokinase-type plasminogen activator (PLAU) gene and vascular dementia (VD) . Methods The polymorphism of PLAU gene rs2227564 in 132 VD patients (VD group) and 121 patients with acute cerebral infarction (control group) was examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP ) technique. The relationship between the polymorphism and the onset of VD was analyzed by Logistic regression. Results In VD group,there were 53 patients (40. 1% ) with C/C genotype of PLAU gene rs2227564,and 72 patients (54. 5% ) with C/T genotype,7 patients (5. 4% ) with T/T genotype; the C allele frequency of PLAU gene rs2227564 was 67. 3% ,and the T allele frequency was 32. 7% . In control group,there were 39 patients (32. 2% ) with C /C genotype of PLAU gene rs2227564,and 63 patients (51. 9% ) with C /T genotype,19 patients (15. 9% ) with T /T genotype; the C allele frequency of PLAU gene rs2227564 was 53. 3% ,and the T allele frequency was 46. 7% . The differences of genotype and allele frequency of PLAU gene rs2227564 between VD group and control group were significant (all P 0. 05) . The Logistic regression analysis showed that the C /C genotype of PLAU gene rs2227564 was the risk factor of the onset of VD (OR = 1. 281,95% CI: 1. 098 - 2. 577,P = 0. 037 ) . Conclusions The PLAU polymorphism is correlated with onset of VD. And the gene C /C genotype of PLAU gene rs2227564 can increase the risk of VD." @default.
- W2389545598 created "2016-06-24" @default.
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- W2389545598 date "2010-01-01" @default.
- W2389545598 modified "2023-09-28" @default.
- W2389545598 title "Association between polymorphism of urokinase-type plasminogen activator gene and vascular dementia" @default.
- W2389545598 hasPublicationYear "2010" @default.
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