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- W2389548027 abstract "Objective Toinvestigate the effect of arsenic trioxide(ATO) on the expression of DNA methyltransferase1 (DNMT1)mRNA and CD11a mRNA in splenic mononuclear cells (SMNC) of spontaneous lupus nephritis MRL/lpr mice. Methods Isolated SMNC of MRL/lpr and C57BL mice were induced by PHA 20g/ml + IL-2 1000IU/ml for 48 h, and the cultured cells were randomly divided into control group, ATO group, 5-AZ group. Each group was incubated in vitro for 24h and RNA was extracted. The expression of DNMT1 and CD11a was determined by RT-PCR. Results The gray scale value of DNMT1-mRNA in ATO group was significantly higher than that in 5-Az group (P0.05)and the gray scale value of CD11a-mRNA in ATO group was significantly lower than that in 5-Az group(P0.05). Conclusion The therapeutic effect of ATO for SLE maybe associated with reversed low DNA methylation." @default.
- W2389548027 created "2016-06-24" @default.
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- W2389548027 date "2008-01-01" @default.
- W2389548027 modified "2023-09-26" @default.
- W2389548027 title "Effects of arsenic trioxide on the expression of DNA methyltransferase 1 and CD(11a) genes in splenic mononuclear cells of spontaneous lupus nephritis MRL/lpr mice" @default.
- W2389548027 hasPublicationYear "2008" @default.
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