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- W2389550265 abstract "Objective To investigate the ototoxicity of cisplatin on distortion product otoacoustic emissions (DPOAE) and high frequency audiometry. Methods DPOAE, conventional pure tone audiometry and expanded high frequency audiometry were examined in 24 gynecologic cancer patients of first time cisplatin administration before and after the chemotherapy. DPOAE amplitudes, conventional pure tone hearing thresholds and expanded high frequency hearing thresholds were compared. Results After the cisplatin administration, the pure tone hearing thresholds at expanded high frequency area declined. DPOAE amplitudes at frequency from 3 to 4 kHz and expanded high frequency area declined too. The obvious change occurred in age group of 19 to 29. Conclusion DPOAE is a potential implement to early detect the ototoxicity of cisplatin. It is likely that the origination of DPOAE does not limit to the outer hair cells in corresponding cochlear areas. The originated area and mechanism of DPOAE should be focused on in further studies. The susceptibility to cisplatin may decline with the increase of patients' age." @default.
- W2389550265 created "2016-06-24" @default.
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- W2389550265 date "2003-01-01" @default.
- W2389550265 modified "2023-09-26" @default.
- W2389550265 title "Clinical study on ototoxicity of cisplatin by distortion product otoacoustic emissions and high frequency audiometry" @default.
- W2389550265 hasPublicationYear "2003" @default.
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