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- W2389551748 abstract "Objective:To investigate the effects of ginkgo bilobate extract on the expression of renal vascular endothelial growth factor( VEGF)mRNA and protein of diabetic nephropathy(DN) in rats.Method:SD rats were divided into control group,diabetic nephropathy group(DN group),ginkgo bilobate extract treated group.DN was induced by peritoneal injection of streptozotocin(STZ),with or without treatment by gastric perfusion of ginkgo bilobate extract daily until 12 weeks after the experiment.The body weights,blood,urine,24 hour total urinary albumin were measured.The expression of VEGF mRNA was determined by reverse transcription-polymerise chain reaction(RT-PCR) and the protein was detected by immunohistochemical staining.Result:The body weight,blood glucose,urinary albumin,expression of VEGF mRNA and protein,glomerular cellularity and extracellular matrix( ECM) increased significantly in nephritic rats without treatment with Ginkqo-damole as compared to those in control rats( P 0.0l).However,the body weight,blood glucose,urinary albumin,expression of VEGF mRNA and protein,ECM decreased significantly in ginkgo bilobate extract treated nephritic rats as compared to thosein nephritic rats without treatment with Ginkqo-damolon (P 0.05).The positive correlations were found between urinary levels of VEGF and urinary albumin(P0.05),and between urinary levels of VEGF and urine creatinine(P0.05).Conclusion:The overexpression of VEGF may participate in the pathogenesis of diabetic nephropathy.Ginkgo bilobate extract could contribute to decrease body weights,blood glouse,urinary albumin excrection,inhibit glomerular cellularity and ECM proliferation,downregulate the-expression of VEGF mRNA and protein." @default.
- W2389551748 created "2016-06-24" @default.
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- W2389551748 date "2010-01-01" @default.
- W2389551748 modified "2023-09-22" @default.
- W2389551748 title "Effects of Ginkgo Bilobate Extract on the Expression of Vascular Endothelial Growth Factor of Diabetic Nephropathy in-Rats" @default.
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