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- W2389567222 abstract "Objective:Study the expression and changes of costimulatory molecule CTLA-4,B7-1 and B7-2 in experimental autoimmune myocarditis(EAM) and explore the pathogenesis of EAM.Methods:EAM model was established by injecting porcine cardiac myosin into Lewis rats(experimental group,n=30),and then the 30 rats were randomly divided into three subgroups in accordance with 14 d,28 d,56 d after the first immunization.HE staining was used to observe the change of histopathological characteristics.Immunohistochemical staining and real-time fluorescence quantitative PCR detection was used to analysis the expression of CTLA-4,CD80,CD86.Results:There were varying degrees of myocarditis change in experimental group;CTLA-4,CD80,CD86 mainly expressed in cardiac cells.After the first immunization,expression of proteins increased gradually from 14 d to 28 d,but decreased in 56 d.Real-time PCR: compared with normal group,the expression of CD80,CD86 mRNA were higher in experimental group(P0.05).Conclusion:The expression of CD80,CD86 and CTLA-4 promotes heart tissue inflammation,and may closely related to the occurrence and development of EAM." @default.
- W2389567222 created "2016-06-24" @default.
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- W2389567222 date "2013-01-01" @default.
- W2389567222 modified "2023-09-25" @default.
- W2389567222 title "The role of costimulatory molecules CTLA-4 and B7 in autoimmune myocarditis" @default.
- W2389567222 hasPublicationYear "2013" @default.
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