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- W2389573485 abstract "Objectives To describe clinical features of measles and to determine influential factors of it since introduction of measles vaccine,and to examine accuracy of measles surveillance case definition in detecting measles currently.Methods After cases missed clinical signs or symptoms were deleted,3041 suspected measles(inclusive of confirmed measles cases and non-measles cases) were selected as sample of the study through Measles Surveillance System from 2004 to 2008.Data regarding sex,age,history of vaccination for measles,and clinical manifestation of illness(i.e.cough,coryza,conjunctivitis) were collected.Results Of 1893 confirmed measles cases,prevalence rates of cough,coryza and conjunctivitis were 97.3%,82.3% and 79.6%,while rates were 74.4%,50.0% and 51.0% of 1148 non-measles cases.There were obvious differences between confirmed measles cases and non-measles cases,the confirmed measles cases were more likely to get cough(χ2=373.107;P0.001),coryza(χ2=355.836;P0.001) and conjunctivitis(χ2=272.085;P0.001) than non-measles cases.Of the three indicators(age,sex,previous vaccination for measles),age and history of vaccination were significantly associated with prevalence of thecoryzasymptom,and history of vaccination were significantly associated with prevalence of the conjunctivitissymptom.After adjusting confounding factorage,compared with measles cases without vaccination cases who were vaccinated once[ORadjusted=0.410(95%CI:0.270,0.623)] and more than once[ORadjusted=0.394(95%CI:0.285,0.545)]were less likely to coryza symptom.Similarly,measles cases vaccinated for measles only once previously tended to be lower at risk forconjunctivitissymptom at presentation[ORcrude= 0.620(95% CI:0.432,0.890)].Cases vaccinated for measles at least two times previously,ORcrude(95%CI) value was 0.618(0.427,0.950).The cases definition of current measles surveillance system had maximum sensitivity(98.9%) but low specificity(12.8%).Specificity(68.2%) was highest when a generalized maculopapular rash,fever,cough,coryza and conjunctivitis were defined as cases.Both Kappa value and ROC figure were more ideal,which was case definition included a generalized maculopapular rash,fever,cough and coryza.Conclusion Currently,laboratory confirmation is essential to ensure an accurate identification of each measles case because actual measles cases may have a mild and atypical presentation during vaccine era.It was crucial to improve accuracy of surveillance for measles that adequate case definition was selected according to incidence on measles elimination progress." @default.
- W2389573485 created "2016-06-24" @default.
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- W2389573485 date "2010-01-01" @default.
- W2389573485 modified "2023-09-23" @default.
- W2389573485 title "Clinical Characteristics of Measles during Vaccine Era and Evaluation of the Case Definition for Measles Surveillance" @default.
- W2389573485 hasPublicationYear "2010" @default.
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