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- W2389580371 abstract "Objective To study the effect of etomidate on the changes in [Ca2+]i in rat cerebrocortical synaptosomes induced by KCI. Methods Freshly isolated SD rat cerebrocortical synaptosomes were prepared. KCI was used as chemical stimulant. Neurochemical method was employed (Fura-2 was used as calcium indicator) . Etomidate was added (the end concentration was 0.4, 4, 40 and 100 μmol·L-1 respectively) before and after stimulation with KCI 50 mmol·L-1 to determine the peak and plateau [Ca2+]i in the cerebrocortical synaptomes. Results Before KCI stimulation etomidate inhibited KCl-evoked increase in intra-synaptosomal [Ca2+ ]i in a concentration-dependent manner. The inhibitory ratio of peak calcium concentration was 5%±3% , 11%±6% , 24%±10% and 33%±12% respectively as compared with control. Etomidate at concentration of 40 μmol·L-1 and above had significant effect on [Ca2+]i. When added immediately after KCI stimulation, 4,40 μmol·L-1 etomidate significantly increased plateau [Ca2+]i in synaptosomes.Conclusion Etomidate alters KC1-induced calcium dynamics in rat cerebrocortical synaptosomes. Presynaptic calcium channels and calcium removal mechanism are involved in its anesthetic action." @default.
- W2389580371 created "2016-06-24" @default.
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- W2389580371 date "2005-01-01" @default.
- W2389580371 modified "2023-09-25" @default.
- W2389580371 title "Effect of etomidate on calcium dynamics in rat cerebrocortical synaptosomes" @default.
- W2389580371 hasPublicationYear "2005" @default.
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