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- W2389583453 abstract "Objective To explore the mechanism of leonurine hydrochloride(LH) on uterine contractions in abortion rats.Methods Early pregnancies in rats had incomplete abortions induced using mifepristone in combination with misoprostol.After the abortions,the rats were treated with LH orally for 7 days and surgery was performed.The sinistro-uterus was dissected for m easurement of endothelin(ET) and nitric oxide(NO).The dextro-uterus was stored at-80 ℃ for ETA and ETB analysis.Myometrial cells from the dextro-uterus were cultured for measurement of phospholipase C(PLC) activity,intra-cellular Ca2+ concentration(i),and protein kinase C(PKC) activity.Results In vivo experiments,the ET level and ET/NO ratio were increased after LH treatment in rats with induced abortions and LH-can up-regulate ETA mRNA expression(P0.01,vs the model group),but there was not ETB mRNA change.LH significantly increased the i,PLC activity,and relative production of PKC protein in myometrial cells.Conclusion LH increased uterine contractions in rats with incomplete abortions by modulating the ET receptor-mediated signal pathway." @default.
- W2389583453 created "2016-06-24" @default.
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- W2389583453 date "2013-01-01" @default.
- W2389583453 modified "2023-09-26" @default.
- W2389583453 title "Effect of leonurine hydrochloride on ET-mediated signal pathway in incomplete abortion in rats" @default.
- W2389583453 hasPublicationYear "2013" @default.
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