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- W2389589080 abstract "Objective: To approach the effect of CYP3A4*18B, CYP3A5*3 and ABCB1 haplotypes on serum tacrolimus(FK506) dose adjusted blood trough concentrations(C0 /D) in Chinese renal transplant re cipients during the first month following surgery. Methods: A total of 46 renal transplant recipients receiv ing FK506 were genotyped by PCR-RFLP. The C0 of FK506 were determined by EMIT. Results: the al lele frequencies of CYP3A4*18B, CYP3A5*3 and ABCB1(C1236T, G2677A/T, C3435T) were 0.304, 0.707, 0.554, 0.478 and 0.304, which fitted Hardy-Weinberg equilibrium. The CYP3A4-3A5, G2677A/T-C3435T and C1236T-C3435T alleles exhibited linkage disequilibrium. There was a significant relationship between CYP3A4*18B and FK506 C0 /D after transplantation, the C0 /D in wild type patients were 1.34 times during days 8~15 and 1.67 times during days 16~30 higher than those in patients with the other two genotypes, respectively. The patients with CYP3A5 homozygote mutants were also found to have marked higher C0/D compared with the other two genotypes, which were 1.56 times in days 1~7, 1.98 times in days 8~15 and 1.99 times in days 16~30, respectively. Haplotype analysis revealed that the FK506 C0 /D were significantly higher in carriers of haplotype CYP3A4/5 GG than in non-carriers, 1.43 times in days 8 ~15 and 1.77 times in days 16 ~30, respectively. Neither polymorphisms nor haplotypes of ABCB1 statistically affected FK506 C0 /D. Conclusion: The data suggest that only the CYP3A4/5 haplotypes affect FK506 C0 /D in Chinese renal transplant patients. Determination of CYP3A4/5 haplotypes is beneficial for adjusting FK506 dosage." @default.
- W2389589080 created "2016-06-24" @default.
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- W2389589080 date "2014-01-01" @default.
- W2389589080 modified "2023-09-23" @default.
- W2389589080 title "Association of CYP3A4/5,ABCB1 Haplotypes with Serum Tacrolimus trough Blood Level in Chinese Renal Transplant Recipients" @default.
- W2389589080 hasPublicationYear "2014" @default.
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