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- W2389589330 abstract "Objective To investigate the effect of Bilirubin on the serum levels of hepatocyte growth factor,renal function and the damage of renal morphology in ischemie acute renal failure(IARF),and to study the protective mechanism of Bilirubin in IARF.Methods Selecting 40 health male rats and randomly dividing them into 3 groups(observation group,sham-operated group and control group).Establishing renal ischemia acute renal failure model.The rats in observation group were pretreated with Bilirubin for 3 days,and others were given physiological saline.Biochemical parameters for serum HGF,blood urea nitrogen(BUN),creatinine(Cr)were measured and renal tissue pathology changed.Results After 4 hours IARF,HGF level in observation group is higher than sham-operated group and control group(P0.01),and there is no difference between sham-operated group and control group(P0.05),the expression level of HGF of IARF 12 hours is higher than IARF 4 hours in control group(P0.01).Blood urea nitrogen(BUN) and creatinine(Cr) in observation group are lower than that in the control group(P0.05),control group observation group is higher than sham-operated group(P0.01).The renal tissue damage of control group is lower than the observation group.Conclusion Bilirubin pretreatment can alleviate the damage of renal function in IARF and Bilirubin can induce the expression of HGF." @default.
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- W2389589330 date "2012-01-01" @default.
- W2389589330 modified "2023-09-26" @default.
- W2389589330 title "Effect of Bilirubin on Ischemic Acute Renal Failure" @default.
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