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- W2389603344 abstract "Objective To explore the effects of icotinib on the cell proliferation and cell cycle in human non-small cell lung cancer(NSCLC)HCC827 cells,and to further investigate the mechanism of action.Methods Cell proliferation was measured by using MTT assay.Cell cycle changes were determined by flow cytometry.The expressions of proteins were detected by Western blot.All experimental data were dealt with SPSS(13.0 soft).Results Icotinib significantly inhibited HCC827 cell viability in a concentration and time dependent manner,the concentration of inhibited cell viability(IC50)for 48 h was 0.60 μmol/L,72 h was 0.06 μmol/L.Icotinib induced significant G1 phase arrest of HCC827 cells in a concentration-dependent manner.Further more,icotinib could upregulated the expression of p21,decreased the expression of cyclin D1 and cyclin A,but had no effect on cyclin E.In addition,after treated 24 h,icotinib could inhibit the expressions of the phosphorylated ERK obviously in HCC827 cells.Conclusions Icotinib inhibited the activation of the ERK signaling pathway,which consequently upregulated the expression of p21,downregulated cyclin D1 and cyclin A in HCC827 cells.Furthermore,MAPK/ERK pathway plays an important role in the biological effects of icotinib." @default.
- W2389603344 created "2016-06-24" @default.
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- W2389603344 date "2013-01-01" @default.
- W2389603344 modified "2023-09-23" @default.
- W2389603344 title "Effects of icotinib on cell cycle arrest in human lung cancer HCC827 cells" @default.
- W2389603344 hasPublicationYear "2013" @default.
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