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- W2389618384 abstract "Objective To investigate the effects of glucocorticoids on interleukin-4(IL-4)/interferon-γ (IFN-γ) and matrix metalloproteinase (MMP)-9,-12,tissue inhibitor of metalloproteinase (TIMP)-1 in smoke-induced chronic obstructive pulmonary disease (COPD) rat models.Methods Male Wistar rats were exposed to cigarette smoke for 3.5 months.Budesonide was nebulized in the last month.Lung function was measured at the end of the study.The levels of IL-4 and IFN-γ in BALF and lung tissues supernant were determined by ELISA.The expression of MMP-9,MMP-12 and TIMP-1 mRNA in lung tissues were determined by RT-PCR.Results (1) In comparison with control group,smoke exposed group presented a significant decrease in FEV_ 0.3 /FVC,Cdyn and a significant increase in Re (P0.05),demonstrating pathologocal features of COPD.After treatment with budesonide,FEV_ 0.3 /FVC,Re and Cdyn were improved obviously (P0.05).(2) The levels of IL-4,IFN-γ and IL-4/ IFN-γ ratio in the lung tissues were (4.74±1.42)pg/ml,(53.12± 29.86)pg/ml and 0.10±0.06 in control group,(17.87±16.57)pg/ml,(19.77±5.58)pg/ml and 0.65±0.46 in smoke exposed group,(6.54±3.10)pg/ml,(75.39±34.17)pg/ml and 0.14±0.10 in budesonide group.There were significant differences in these indexes between smoke exposed group and control group or between budesonide group and smoke exposed group (P0.05).(3) The expression of MMP-12 mRNA and MMP-12/TIMP-1 ratio in smoke exposed group were significantly higher than those in control group (P0.05) but there was no difference in TIMP-1 mRNA (P0.05).The expression of MMP-12 mRNA in budesonide group was significantly lower than that in smoke exposed group.TIMP-1 mRNA and MMP-12/TIMP-1 ratio in budesonide group were similar with those in smoke exposed group (P0.05).Conclusions Budesonide could antagonize the alterations of IL-4 and IFN-γ induced by smoke exposure which might be one of mechanisms in improving lung function but had minimal effect on MMP-12/TIMP-1 ratio when given in the late phase of smoke exposure." @default.
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- W2389618384 date "2004-01-01" @default.
- W2389618384 modified "2023-09-27" @default.
- W2389618384 title "Effects of glucocorticoids on interleukin-4/interferon-γ and matrix metalloproteinases in rat models of smoke-induced chronic obstructive pulmonary disease" @default.
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