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- W2389622126 abstract "Objective:To study the expression and significance of proliferating cell nucler antigen(PCNA)and Ki-67 antigen in salivary gland cancer.Methods:38 cases of salivary gland cancer(17 cases of mucoepidermoid carcinoma;12 cases of adenoid cystic carcinoma;9 cases of malignant plemorphic adenoma.)were examined with anti-PCNA and anti-Ki-67 protein McAbs using immunohistochemical methods.Results:The PCNA and Ki-67 proliferating index(PI)of mucoepidermoid carcinoma and adenoid cystic carcinoma were different in different histologic grade.There were significant difference bwtween high grade mucoepidermoid and low grade mucoepidermoid,adenoid cystic carcinma with solid patten and adenoid cystic carcinma with tubular/cribriform patten.The PCNA and Ki-67 proliferating index(PI)of malignant pleomorphic adenoma were significantly higher than those of adenoid cystic carcinoma and mucoepidwemoid carcinoma.The positivity degree of PCNA and Ki-67 in salivary gland cancers were significantly related to neoplasm clinical behavior(recurrence and metastasis).Conlusion:The proliferating index of Ki-67 and PCNA could be used as an important parameter for grading mucoepidermoid carcinoma and adenoid cystic carcinoma,and as one of adjuvant diagnostic criteria of malignant pleomorphic adenoma.The higher levels of PCNA and Ki-67 may indicate a poor prognosis for the patients with salivary gland carcinoma." @default.
- W2389622126 created "2016-06-24" @default.
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- W2389622126 date "2007-01-01" @default.
- W2389622126 modified "2023-09-24" @default.
- W2389622126 title "Expression of Proliferating Cell Nucler Antigen and Ki-67 Antigen in Salivary Gland Cancer" @default.
- W2389622126 hasPublicationYear "2007" @default.
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