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- W2389623654 abstract "Objective To detect the pathogenic mechanism of early abdominal aortic aneurysm (AAA).Methods Experimental AAA model was made by elastase perfusion and the specimens were harvested on the postoperative day 3,7,14 and 28 respectively.The dilatation rate of aorta was calculated.HE staining and Verhoeff-van Gieson staining were performed to observe the elastic fiber disruption and inflammatory cell infiltration,and in situ hybridization was applied to detect the expression of HO-1 mRNA in aortic wall.The protein expression of ICAM-1 and CD68 was detected by immunohistochemical staining.Results After perfusion,the dilation was increased and experimental AAA model successfully established on the postoperative day 7.The HO-1 mRNA expression was detectable on the postoperative day 3,and peaked on the postoperative day 14,which showed significant difference in comparison with other time points (P 0.01).The expression of ICAM-1 and CD68 protein peaked on the postoperative day 7,14 respectively (P 0.01).Conclusion HO-1 gene was strongly expressed in early AAA,together with elastic fiber disruption and inflammatory cell infiltration." @default.
- W2389623654 created "2016-06-24" @default.
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- W2389623654 date "2005-01-01" @default.
- W2389623654 modified "2023-09-25" @default.
- W2389623654 title "The dynamic expression of heme oxygenase-1 in early abdominal aortic aneurysm in rats" @default.
- W2389623654 hasPublicationYear "2005" @default.
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