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- W2389631441 abstract "Objective:To observe the effects of alcohol extract of Rhizoma Dioscoreae Bulbiferae on the tumor growth and serum interleukin-8(IL-8) and soluble intercellular adhesion molecule-1(sICAM-1) levels in nude mice with human gastric cancer xenograft.Methods:A subcutaneous gastric cancer xenograft model was established in nude mice.Then,the mice were randomly divided into model control group(n = 10),5-FU treatment group(n = 10),and low-dose and high-dose alcohol extract of Rhizoma Dioscoreae Bulbiferae(AERDB) groups(n = 10 each).The four groups received subcutaneous injection of saline,intraperitoneal injection of 5 FU(30 mg/kg),or intraperitoneal injection of alcohol extract of Rhizoma Dioscoreae Bulbiferae(50 mg/kg or 100 mg/kg).The mice were sacrificed after 3 weeks of treatment;blood was collected from the orbit,and serum IL-8 and sICAM-1 levels were measured by enzyme-linked immunosorbent assay;tumor was separated from each mouse,tumor volume and weight were measured,and tumor inhibition rate was calculated.Results:The high-dose AERDB group had significantly lower tumor volume and weight than the model control group(P 0.05).There were no significant differences in tumor volume and weight between low-dose and high-dose AERDB groups(P 0.05).The 5-FU treatment group,low-dose AERDB group,and high-dose AERDB group had tumor volume inhibition rates of 25.00%,17.86%,and 39.29%,respectively,and tumor weight inhibition rates of 37.50%,25.00%,and 43.75%,respectively.The 5-FU treatment group and low-dose and high-dose AERDB groups had significantly lower serum IL-8 and sICAM-1 levels than the model control group(P 0.05).The high-dose AERDB group had significantly lower serum IL-8 and sICAM-1 levels than the low-dose AERDB group(P 0.05) and a significantly lower serum IL-8 level than the 5-FU treatment group(P 0.05).Conclusion:Alcohol extract of Rhizoma Dioscoreae Bulbiferae has a marked tumor-suppressing effect in nude mice with gastric cancer xenograft.Its action mechanism may be related to down-regulation of IL-8 and sICAM-1 expression." @default.
- W2389631441 created "2016-06-24" @default.
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- W2389631441 date "2013-01-01" @default.
- W2389631441 modified "2023-09-27" @default.
- W2389631441 title "Effects of alcohol extract of Rhizoma Dioscoreae Bulbiferae on tumor growth and serum IL-8 and sICAM-1 levels in nude mice with human gastric cancer xenograft" @default.
- W2389631441 hasPublicationYear "2013" @default.
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