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- W2389633161 abstract "Objective To study the influence of different concentrations of resistin on macrophagic lipid phagocytic function during atherosclerosis process. Mathods By using fluorescent quantitative polymerase chain reaction, we examined the mRNA level of resistin in the monocyte-derived macrophages(MDMs) that were treated with ox-LDL. Monocyte cell line THP-1 was selected for analyzing the changes of cholesterol ester by staining with Nile red, a vital dye specific for intracellular lipid droplets, when the THP-1-derived macrophages(THP-1 M) was treated with resistin. Real-time PCR, Western blot and flow cytometry were also used to reveal the expression patterns of SRA, CD36 in mRNA and protein levels for resistin-treated THP-1 M. Results It was found that ox-LDL at concentration 50μg/mL was able to up-regulate gene expression of resistin in MDM and reached its peak level on 4 h, given a 4-fold expression as compared with that in the control treated with non-oxidized LDL(nLDL). However, the Nile red staining showed that exogenous resistin at 100 ng/mL increased significantly the fluorescence intensity of lipid in THP-1 M cells. Resistin also promoted expressions of CD36, a type 2 scavenger receptort in a time-and dose-dependent manner but not for expression of type 1 scavenger receptor SRA. Conclusion The expression of resistin in MDM could be promoted by stimulating with ox-LDL. Exogenous resistin is able to up-regulate CD36 expression at mRNA and protein levels, and to increase the lipid phagocytic power of macrophages resulting in lipids accumulation and formation of foam cells which seems to be related to the initiation and progression of atherosclerosis. (Shanghai Med J, 2006, 29,702-707)" @default.
- W2389633161 created "2016-06-24" @default.
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- W2389633161 date "2006-01-01" @default.
- W2389633161 modified "2023-10-03" @default.
- W2389633161 title "Influence of resistin on macrophagic lipid phagocytic function during formation of atherosclerosis" @default.
- W2389633161 hasPublicationYear "2006" @default.
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