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- W2389634796 abstract "Objective:To investigate the in vivo therapeutic activity of viable lactobacillus against vaginitis caused by mixed infection with S.aureus,E.coli and C.albicans in rabbits and to explore the role of viable lactobacillus in improving the vaginal flora.Methods:Vaginae of rabbits were topically infected with S.aureus,E.coli and C.albicans to induce experimental mixed infectious vaginitis.Rabbit vaginitis was topically treated with three doses of viable lactobacillus suspension(6.31×108,3.15×108 and 1.58×108 cfu/mL·kg-1 for 7 days.Combination Levofloxacin hydrochloride(15 mg/kg) with fluconazol(1 mg/kg)acted as positive control.The efficacy of viable lactobacillus against vaginitis was evaluated by observed vaginal appearance,vaginal secretions smear test with microscope,selective microorganism culture of secretions and vaginal mucosa histopathology examination.Results:⑴Significant difference was observed in vaginal appearance,vaginal secretions smear leukocyte test with Gram staining and bacteriological examination between control group and negative high dose group or positive control group.⑵Negative results of S aureus culture and E coli culture were observed in high and medium dose groups.Significant difference was observed.⑶C.albicans culture showed the negative results in all groups but negative control group.⑷3/5 rabbits in high dose group showed lactobacillus positive culture after treatment,which indicated improvement in vagina environment.In contrast,lactobacillus negative culture was found in positive control group,which indicated that vaginal inflammatory could be cleared after treatment with antibiotics,without recovery in vagina environment.⑸ Vaginal mucosa histopathology examination showed that inflammatory reaction was improved with a dose-effect relationship after treatment.The average score and therapeutic effect assessment before and after treatment in all groups show that the effective rates were 90.32%,68.42% and 18.42% in high,medium and low dose group respectively.In addition to ameliorating inflammatory,high dose viable lactobacillus could rebalance normal flora in vagina environment.Conclusion:Viable lactobacillus have remarkable therapeutic effects on vaginitis caused by mixed infection with S.aureus,E.coli and C.albicans and improve the vaginal flora." @default.
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- W2389634796 date "2011-01-01" @default.
- W2389634796 modified "2023-09-23" @default.
- W2389634796 title "Therapeutic Effects of Viable Lactobacillus against Vaginitis Caused by Mixed Infection with S.aureus,E.coli and C.albicans in Rabbit" @default.
- W2389634796 hasPublicationYear "2011" @default.
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