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- W2389634905 abstract "Objective:To screen and identify the genes relating to the metastasis of human hepatocellular carcinoma (HCC). Methods:The difference of gene expression profiles between the HCC tissue with and without metastasis were analyzed by oligo nucleotide microarray. Based on the findings of this gene expression profiling and the previous molecular cytogenetic studies, the leading differently expressed genes were identified and selected for further analysis by semi-quantitative RT-PCR. Results: 989 differently expressed genes were detected between the HCC tissues with and without metastasis. One of the leading candidate genes on chromosome 8p, FGL1, was identified. And RT-PCR analysis demonstrated that FGL1 gene was significantly down-regulated in the HCC tissues with metastasis, which further confirmed the results of the gene chips technique. Conclusion: The gene expression profiles were significantly different between the HCC tissues with and without metastasis. FGL1 on chromosome 8p might possess metastasis suppressor activity in HCC." @default.
- W2389634905 created "2016-06-24" @default.
- W2389634905 creator A5036663930 @default.
- W2389634905 date "2006-01-01" @default.
- W2389634905 modified "2023-09-23" @default.
- W2389634905 title "PGL1,a Candidate Metastatic Suppressor Gene of Human Hepatocellular Carcinoma" @default.
- W2389634905 hasPublicationYear "2006" @default.
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