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- W2389637710 abstract "Simulated moving bed chromatography (SMBC) has become an important technology for resolution of chiral drugs, and the key of its technical using relies on the determination of the optimum operation conditions. Since the SMBC process is quite complex, to determine the optimum operation point through mathematical model is not so easy and it needs a long calculation time. In this paper, a simulated moving bed model considering the mass transport resistance and axial dispersion was set up. The proposed model was transferred into a series of ordinary differential equations (ODEs) with the method of lines. The ODEs were then solved by ODE solvers provided by MATLAB. Using the proposed model, the separation of Omeprazole enantiomers by simulated moving bed chromatography was simulated. The results show that the solving of the simulation is very quick and accurate, and the proposed model and solving method could be used for real time optimization and control." @default.
- W2389637710 created "2016-06-24" @default.
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- W2389637710 date "2005-01-01" @default.
- W2389637710 modified "2023-09-25" @default.
- W2389637710 title "Simulation of Omeprazole Resolution by Simulated Moving Bed Chromatography" @default.
- W2389637710 hasPublicationYear "2005" @default.
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