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- W2389640384 abstract "Objective To study the effect of total salvianolic acid from Salvia miltiorrhiza f.alba(TSAS) on rat models with thromboangiitis obliterans(TAO) and provide basis for treatment of this disease.Methods Principal components analysis in TSAS was carried out by LC-UV-MS.Wistar rats were randomly divided into six groups,such as Sham,model,TSAS high-,mid-,and low-dose(5.63,2.82,and 1.41 g/kg) groups,as well as Tongsemai Tablets(0.66 g/kg) as positive group.TAO model was prepared by iv injecting lauric acid solution into the femoral artery of rats and on the second day the rats were ig administrated with TSAS and Tongsemai Tablets,respectively once a day for a week.The changes of physical signs and pathologic grading of vascular smooth muscle and fibrous tissue were observed and the levels of thromboxane B2(TXB2),endothelin(ET),and 6-keto-prostaglandin Flα(6-k-PGF1α) in serum were detected.Results TSAS significantly reduced the degree and scope of limb lesion in animals of treating group,with the inflammatory reaction and number of thrombus formatron inhibited,decreased the levels of TXB2 and ET,while increased the level of 6-k-PGF1αin serum.Conclusion TSAS has the significant therapeutic effect on the experimental TAO prepared among rats.The possible mechanisms for this effect may be achieved by improving anti-oxidative function of vessel endothelia and inhibiting the inflammatory reaction in vascular wall." @default.
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- W2389640384 date "2012-01-01" @default.
- W2389640384 modified "2023-09-28" @default.
- W2389640384 title "Effects of total salvianolic acid from Salvia miltiorrhiza f.alba on thromboangiitis obliterans in rats" @default.
- W2389640384 hasPublicationYear "2012" @default.
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