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- W2389640774 abstract "Objective:To investigate the effects of Angelica Sinensis polysaccharide(ASP) on oxygen free radicals of experimental colitis in rats.Methods:The classic colitis model of rats was induced by intracolon enema with 2,4,6-trinitrobenzene sulfonic acid(TNBS) and ethanol. The experimental animals were randomly categorized into 5 groups: normal group, model group, and 3 ASP groups, treated intracolicaly with saline, saline and ASP(250,500,1?000?mg/kg) respectively and daily for 21 days. The myeloperoxidase(MPO) activity and the levels of SOD MDA and GSH-Px in the colon tissue were measured. Meantime, histopathological score (HS) of the colon tissue was evaluated.Results:The activities of SOD and GSH-Px were significantly decreased while the MDA content, MPO activity and HS were remarkably elevated in model group. ASP not only increased the activities of SOD and GSH-Px but also reduced the MDA content and MPO activity in a dose-dependent manner in model group. ASP also ameliorated the HS.Conclusions:ASP have protective effect on colon injury of experimental colitis rats, which may be related with its anti-oxidation property." @default.
- W2389640774 created "2016-06-24" @default.
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- W2389640774 date "2003-01-01" @default.
- W2389640774 modified "2023-09-28" @default.
- W2389640774 title "Effect of Angelica Sinensis polyasccharide on oxygen free radicals in experimental colitis of rats" @default.
- W2389640774 hasPublicationYear "2003" @default.
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