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- W2389647191 abstract "Objective: Determine the levels of Antisperm Antibody (AsAb) in serum samples and Interferon γ(IFN γ) in supernatants of peripheral blood cell culuter of infertility. In order to study the correlation between AsAb and IFN γ,explore the relationship between AsAb , IFN γ and infertility and the pathogenisis.Methods: Enzymelinked Immunosorbent Assay (ELISA) was applied to determine the AsAb in serum samples of 62 women with infertility and that of 50 women with normal pregnant history. Furthermore,the level of IFN γ in supernatants of peripheral blood cell culture was measured by ELISA in 50 women with infertility and 50 women with normal pregnant history. Results: ⑴ The positive rate of serum AsAb in the patients of infertility 29.03% (18 of 62) is significantly higher than that of women with normal pregnant history 6.00% (3 of 50)(P0.05). ⑵ The supernatant IFN γ level in infertility women is significantly higher than that of women with normal pregnant history (1.100±0.459) μg/L vs (0.607±0.052) μg/L (P0.001).⑶The supernatant IFN γ level in AsAb positive group is significantly higher than that of AsAb negative group (1.308±0.345) μg/L vs (0.836±0.265) μg/L(P0.001). ⑷ The supernatant IFN γ level correlated with serum AsAb level (r=0.812 6, P0.001).Conclusion: ⑴ AsAb is an important immune factor,there is relative relationship between AsAb and infertility. ⑵ The supernatant IFN γ level in infertily patients is significantly higher than that of normal pregnant women,indicate that the state of cellular immunity in patients is abnormally active. Abnormally increasing IFN γ can contribute to infertility by affecting organism immune reactivity. ⑶ There is relevant correlation between the abnormally increasing IFN γ level and that of AsAb in the infertity patients." @default.
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- W2389647191 date "2000-01-01" @default.
- W2389647191 modified "2023-09-23" @default.
- W2389647191 title "The study on correlation between immune factor AsAb, IFN γ-in infertility" @default.
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