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- W2389649303 abstract "Objective To investigate antiangiogenic effects on TIMP-2 in colorectal carcinoma. Methods 40 cases of colorectal carcinoma patients were examined with immunohistochemical staining (S-P method)by using anti-TIMP-2 and anti-factor CD34(+) monoclonal antibodies. Results TIMP-2 was positive [57.5% (23/40)] in adjacent mucosa of colon cancer. That was higher than that in its primary foci [35.0%(14/40)] of colon cancer. TIMP-2 expression in primary foci was closely correlated with tumor invasive depth,metastasis and DUKES staging of colon cancer (P0.05) despite showing no significant relationship between its expression and differentiation(P 0.05). The results suggested positive correlation of mean MVD with tumor depth of invasion,metastasis and DUKES staging(P 0.05),but no relationship was found between mean MVD and differentiation in colon cancer (P 0.05). A significant negative correlation was revealed between the TIMP-2 and MVD.Conclusion There is certain antagonist between the expression of MVD and TIMP-2 in human colon cancer. By interfering with the process of degradation of extracellular matrix and the angiogenesis,TIMP-2 plays an important role in growth,invasion,metastasis and angiogenesis in colon cancer ." @default.
- W2389649303 created "2016-06-24" @default.
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- W2389649303 date "2004-01-01" @default.
- W2389649303 modified "2023-09-26" @default.
- W2389649303 title "Antiangiogenic effects on TIMP-2 in colon cancer" @default.
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