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- W2389654841 abstract "OBJECTIVE To investigate the effect of L-tetrahydropalmatine on synaptic function after ischemia and reperfusion in hippocampal slices.METHODS Rat hippocampal slices placed in two compartment of a dual chamber were immersed in the superfusing artificial cerebral fluid(ACSF)with 95% O2+5%CO2.The population spike(PS) were recorded in CAl pyramidal cells by stimulating Schffer collateral pathways.The appearance time of attenuation and disappearance time of PS,the appearance of hypoxic injury potential and the recovery rate of PS after reoxygenation were recorded.RESULTS After the treatment with L-tetrahydropalmatine at the doses of 0.028,0.14,0.28 mmol·L-1,the appearance of attenuation and disappearance of population spike(PS) were significantly postponed comparing with the ischemia group.The appearance of hypoxic injury potential(HIP) was delayed significantly and the appearance probability of HIP was lower in L-tetrahydropalmatine group and the recovery amplitude of PS after reoxygenation was significantly higher than that of oxygen-glucose deprivation(OGD) group.CONCLUSION L-THP increased the ability against brain hypoxic injury and relieved the reversible and irreversible hypoxic injury in hippocampal slices." @default.
- W2389654841 created "2016-06-24" @default.
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- W2389654841 date "2007-01-01" @default.
- W2389654841 modified "2023-09-26" @default.
- W2389654841 title "Effects of L-Tetrahydropalmatine on Electrophysiological Changs Induced by Ischemia in Hippocampal Slices" @default.
- W2389654841 hasPublicationYear "2007" @default.
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