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- W2389658601 abstract "Objective To explore the relationship between gastric mucosal ischemia and inflammatroy mediators released in rats with acute necrotizing pancreatits(ANP).Methods A total of 64 rats were randomized into control group and ANP group.The ANP model was induced by injection of 5% sodium taurocholate under the pancreatic capsule.Radioactive biomicrosphere technique was used to measure the gastric mucosal blood flow(GMBF) at 2h and 12h after the induction of ANP,meanwhile,blood and gastric tissue sample were taken for observation of phospholipaseA 2(PLA 2),interleukin 1β(IL 1β)levels and gastric mucosal pathological changes.Results Comparing control group,the PLA 2 and IL 1β levels in serum increased significantly,the GMBF reduced significantly at 2h and 12h after induction of ANP(all P0.001).GMBF was closely correlated with PLA 2 and IL 1β levels in serum(P0.05).Conclusion The reduction of GMBF and the increasement of inflammatory mediators developed simultaneously in ANP early,hence both of them are important pathogenic factors of gastric mucosal injury in ANP." @default.
- W2389658601 created "2016-06-24" @default.
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- W2389658601 date "2003-01-01" @default.
- W2389658601 modified "2023-09-25" @default.
- W2389658601 title "THE RELATIONSHIP BETWEEN GASTRIC MUCOSAL ISCHEMIA AND INFLAMMATORY MEDIATORS IN RATS WITH ACUTE NECROTIZING PANCREATITIS." @default.
- W2389658601 hasPublicationYear "2003" @default.
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