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- W2389659310 abstract "AIM:To detect and analyse interleukin-6 in periodontal tissue and serum CRP levels in the model of chronic periodontitis associated with atherosclerosis of rats. METHODS: Sixty adult male Wistar rats were randomly divided into four groups: group A(control group), group B(periodontitis group), group C(atherosclerosis group) and group D(periodontitis associated with atherosclerosis group). Every group accepted the corresponding treatment. Pathological changes in periodontal tissue of experimental teeth and arterial vessels were observed. Semi-quantitate analyss of IL-6 in periodontal tissue was done by immunohistochemistry method. CRP level in serum was assayed by ELISA. RESULTS: Histopathology observation of periodontal tissue was as follows. Obvious inflammation of periodontal tissue was observed in group B and D. Attachment loss level in group B and D was higher than that in group A and C(P0.05). Histopathology observation of arteries revealed that tunica media of artery thickened in group B and that thoracic aorta and abdominal aorta atherosclerotic lesions wene formed in group C and D. IL-6 in periodontal tissue and serum levels of CRP in group B and D were higher than in other groups (P0.05). Dependablity analyse showed that CRP and IL-6 in both group B and D were positive correlation. CONCLUSION: Atherosclerosis and periodontitis could influence each other,the development of two diseases may concerne with elevated levels of inflammatory factors." @default.
- W2389659310 created "2016-06-24" @default.
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- W2389659310 date "2009-01-01" @default.
- W2389659310 modified "2023-09-28" @default.
- W2389659310 title "Expression of inflammatory cytokines in the model of chronic periodontitis associated with atherosclerosis of rats" @default.
- W2389659310 hasPublicationYear "2009" @default.
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