Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389662014> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2389662014 abstract "Objective To investigate the immunoregulatory effect of recombinant human growth hormone(rhGH) on the rats with sepsis.Methods Male Wistar rats were randomized into 3 groups:high,low dose rhGH group [3 and 1?U/(kg·d)] and control group(normal saline solution).rhGH or saline solution were administered subcutaneously for 5 days.Then the rats were challenged with E coli lipopolysaccharide(10?mg/kg) via tail vein 12 hours after the last subcutaneous administration of rhGH or saline solution.Finally,serum TNF-α and IL-10 level before and after lipopolysaccharide challenge were measured.Results There was no significant difference in serum TNF-α or IL-10 among the three groups before lipopolysaccharide challenge(P0.05).The serum TNF-α and IL-10 levels in the control group tended to be higher compared with the prechallenge levels,and risen significantly at 4 hours after lipopolysaccharide challenge(P0.001).However,TNF-α levels in the high and low dose groups were significantly lower than that in the control group at 1 to 4 hours after lipopolysaccharide challenge(P0.005).IL-10 level at 2 hour was significantly higher in the high dose group as compared with the control group(P0.001),but IL-10 level in the high and low dose groups was significantly lower than that in the control group at 4 hour after lipopolysaccharide challenge(P0.005).Conclusion GH can inhibit excessive TNF-α release in the early stage of sepsis and exert biphasic effect on IL-10 expression(GH inhibits inflammatory response in the early stage and avoids excessive inhibition).GH can modulate cytokine network and correct the immune dysfunction in the rat with sepsis." @default.
- W2389662014 created "2016-06-24" @default.
- W2389662014 creator A5069752194 @default.
- W2389662014 date "2006-01-01" @default.
- W2389662014 modified "2023-09-24" @default.
- W2389662014 title "Study on protecting mechanism of growth hormone on the rats with sepsis" @default.
- W2389662014 hasPublicationYear "2006" @default.
- W2389662014 type Work @default.
- W2389662014 sameAs 2389662014 @default.
- W2389662014 citedByCount "0" @default.
- W2389662014 crossrefType "journal-article" @default.
- W2389662014 hasAuthorship W2389662014A5069752194 @default.
- W2389662014 hasConcept C126322002 @default.
- W2389662014 hasConcept C134018914 @default.
- W2389662014 hasConcept C17991360 @default.
- W2389662014 hasConcept C2776390293 @default.
- W2389662014 hasConcept C2777397205 @default.
- W2389662014 hasConcept C2778384902 @default.
- W2389662014 hasConcept C2778754761 @default.
- W2389662014 hasConcept C2984496839 @default.
- W2389662014 hasConcept C2994100043 @default.
- W2389662014 hasConcept C71315377 @default.
- W2389662014 hasConcept C71924100 @default.
- W2389662014 hasConceptScore W2389662014C126322002 @default.
- W2389662014 hasConceptScore W2389662014C134018914 @default.
- W2389662014 hasConceptScore W2389662014C17991360 @default.
- W2389662014 hasConceptScore W2389662014C2776390293 @default.
- W2389662014 hasConceptScore W2389662014C2777397205 @default.
- W2389662014 hasConceptScore W2389662014C2778384902 @default.
- W2389662014 hasConceptScore W2389662014C2778754761 @default.
- W2389662014 hasConceptScore W2389662014C2984496839 @default.
- W2389662014 hasConceptScore W2389662014C2994100043 @default.
- W2389662014 hasConceptScore W2389662014C71315377 @default.
- W2389662014 hasConceptScore W2389662014C71924100 @default.
- W2389662014 hasLocation W23896620141 @default.
- W2389662014 hasOpenAccess W2389662014 @default.
- W2389662014 hasPrimaryLocation W23896620141 @default.
- W2389662014 hasRelatedWork W11766024 @default.
- W2389662014 hasRelatedWork W2078093373 @default.
- W2389662014 hasRelatedWork W2080976425 @default.
- W2389662014 hasRelatedWork W2148475453 @default.
- W2389662014 hasRelatedWork W2349203250 @default.
- W2389662014 hasRelatedWork W2349909061 @default.
- W2389662014 hasRelatedWork W2350222633 @default.
- W2389662014 hasRelatedWork W2357597818 @default.
- W2389662014 hasRelatedWork W2368624583 @default.
- W2389662014 hasRelatedWork W2373101796 @default.
- W2389662014 hasRelatedWork W2377512382 @default.
- W2389662014 hasRelatedWork W2382487214 @default.
- W2389662014 hasRelatedWork W2390896871 @default.
- W2389662014 hasRelatedWork W2397546568 @default.
- W2389662014 hasRelatedWork W2408210327 @default.
- W2389662014 hasRelatedWork W2587091059 @default.
- W2389662014 hasRelatedWork W3029051137 @default.
- W2389662014 hasRelatedWork W3030621925 @default.
- W2389662014 hasRelatedWork W3143110916 @default.
- W2389662014 hasRelatedWork W2169596877 @default.
- W2389662014 isParatext "false" @default.
- W2389662014 isRetracted "false" @default.
- W2389662014 magId "2389662014" @default.
- W2389662014 workType "article" @default.