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- W2389662336 abstract "Aim:To prepare triamcinolone-acetonide-acetate(TAA)loaded nanostructured lipid carriers(NLC)and investigate their transdermal absorption behavior.Methods:The high-pressure homogenization technique was used to prepare TAA-loaded NLC(TAA-NLC).The morphology,physical structure,particle size with polydispersity index(PI)and Zeta potential were examined by atomic force microscopy(AFM),differential scanning calorimetry(DSC)and photon correlation spectroscopy(PCS),respectively.The entrapment efficiency,stability and in vitro drug release were also studied.The transdermal drug permeation through porcine ear skin was evaluated using modified Franz diffusion cells.Results:The obtained TAA-NLC assumed spherical shape with the average size of(106.47±4.65)nm,PI of 0.176±0.035,Zeta potential of-(45.18±2.73)mV and the entrapment efficiency of(93.06±3.52)%.Drug release profile in vitro was in accordance with Higuchi equation and TAA-NLC had good stability.In comparison with TAA ethanol solution,TAA-NLC resulted in higher drug deposition within porcine ear skin after 24 h penetration experiment.Conclusion:These results indicated that the studied TAA-NLC system with improved drug permeation into skin might be a novel vehicle for the topical use of TAA." @default.
- W2389662336 created "2016-06-24" @default.
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- W2389662336 date "2007-01-01" @default.
- W2389662336 modified "2023-09-26" @default.
- W2389662336 title "Preparation and transdermal absorption of triamcinolone-acetonide-acetate loaded nanostructured lipid carriers" @default.
- W2389662336 hasPublicationYear "2007" @default.
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