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- W2389662340 abstract "Objective To investigate the expression of scavenger receptor A(SR-A) in rat liver tissues during acute obstructive suppurative cholangitis(AOSC) and its relations with inflammatory mediators and hepatic injury.Methods Wistar rat models of AOSC were reproduced by ligating choledochus and inside injecting Escherichia coli O111∶B4.The plasma endotoxin concentrations,TNF-α levels and expressions of SR-A protein and mRNA in liver tissues were assayed by limulus test,ELISA,immunohistochemistry and RT-PCR,respectively.Pathological changes of liver tissues were observed under light microscope.Results With the time prolonged,the plasma endotoxin concentrations and the TNF-α levels gradually increased,but the SR-A protein and mRNA expressions decreased in the rats of experimental group,significantly different with those in sham operation group and normal saline group(P0.05).Meanwhile,the hepatic injury was gradually aggravated.Conclusion With the decreased expression of SR-A in liver tissues during AOSC,the Kupffer cells' abilities of clearing and inactivating endotoxin are down-regulated,and simultaneously Kupffer cells produce and release more cytokines that may initiate and aggravate liver injury." @default.
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- W2389662340 date "2008-01-01" @default.
- W2389662340 modified "2023-09-26" @default.
- W2389662340 title "Significance of scavenger receptor A in rat liver tissues during acute obstructive suppurative cholangitis" @default.
- W2389662340 hasPublicationYear "2008" @default.
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