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- W2389664985 abstract "Objective To investigate whether intensive multifactorial intervention can improve carotid intima-media thickness(IMT) in incipient patients with type 2 diabetes mellitus(T2DM) and to analyze factors influencing IMT.Methods 175 incipient T2DM patients were treated with intensive multifactorial intervention that targeted hyperglycemia,hypertension and dyslipidemia and were followed up for three years.Blood pressure(BP),fasting blood glucose(FBG) and 2-hour postprandial blood glucose(2 hPG) were measured per month.Glycated hemoglobin(HbA1c),fasting insulin(FINS),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),uric acid(UA),body mass index(BMI) and waist circumference(WC) were monitored twice a year.Carotid IMT was measured per year.Insulin resistance index(HOMA-IR),coefficient of variation of fasting blood glucose(CV-FBG) and coefficient of variation of 2-hour postprandial blood glucose(CV-2 hPG) were calculated.Clinical data of IMT increasing group and IMT normal group in T2DM patients at the first diagnosis were analyzed.After three years following up,the patients were divided into IMT increasing group and IMT decreasing group according to the progression of IMT and the associated factors were analyzed.Results(1) According to the first diagnosis,patients in the IMT increasing group were significantly older than the IMT normal group and had significantly higher proportion of hypertension(P0.01).(2) IMT at the first diagnosis and the third year following up showed statistically significant differences(P0.05).(3) After three years following up,BMI,WC,SBP,DBP,CV-2 hPG and UA value in the IMT increasing group were significantly higher than the IMT decreasing group(P0.05).(4) Multivariate regression analysis showed that history of hypertension,2 hPG-CV and BMI were positively correlated with IMT changes(P0.05).Conclusion Intensive multifactorial intervention can improve the carotid IMT in diabetic patients.Hypertension,2 hPG-CV and BMI are significant risk factors for the increase of IMT." @default.
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- W2389664985 date "2012-01-01" @default.
- W2389664985 modified "2023-09-24" @default.
- W2389664985 title "Effect of Intensive Multifactorial Intervention on the Progression of Carotid Intima-Media Thickness in Incipient Patients with Type 2 Diabetes" @default.
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