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- W2389671678 abstract "Objective:To investigate the clinical value of chorionic villi karyotype analysis after abnormal first-trimester(11~13+6 week)ultrasonographic findings in early prenatal diagnosis of fetal chromosome abnormalities,and compare incidence rate of chromosome abnormalities among different ultrasonographic indicators. Methods:Chorionic villi karyotype analysis was performed in all 134 cases with abnormal first-trimester ultrasonographic findings. According to the types of ultrasonographic findings,134 cases were classified into two groups:pure ultrasound soft markers group(95 cases)and structural malformations group(39 cases). The incidence rate of each ultrasonographic indicator and discrepancy between these two groups were analyzed. Results:G-banding karytyping after chorionic villi cell culture was successfully performed on all 134 cases. Of 134 cases,fetal chromosome abnormalities were found in 38 cases and the incidence rate of chromosome abnormalities was 28.4%(38/134). Among 38 cases with chromosome abnormalities,chromosomal trisomy and monosomy were the main abnormalities,accounting for 76.3%(29/38)of abnormal karyotypes. The incidence rate of chromosome abnormalities in structural malformation group(46.2%,18/39)was higher than that in pure ultrasound soft markers group(10.4%,8/77). The difference is statistically significant(P0.05). The most common soft markers were increased nuchal translucency and absence of nasal bone in pure ultrasound soft markers group,the incidence rate of chromosome abnormalities of the former was 28.1%(20/65)and the later was 19.4%(6/31). And The incidence rate of chromosome abnormalities in fetuses with multiple ultrasound soft markers(66.7%,12/18)was higher than that in fetues with single ultrasound soft markers(10.4%,8/77). The difference is statistically significant(P0.05). The most common structural malformations were multiple malformations and hydrops fetalis in structural malformations group,the incidence rate of chromosome abnormalities of the former was 57%(8/14)and the later was 87.5%(7/8). Conclusion:Abnormal first-trimester ultrasonographic findings,which the incidence rate of chromosome abnormalities in fetuses with structural malformations was significant higher than that in fetuses with pure ultrasound soft markers,are of high predictive value for fetal chromosome abnormalities. And fetal chromosome abnormalities could be efficiently detected in the first trimester by chorionic villi karyotype analysis." @default.
- W2389671678 created "2016-06-24" @default.
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- W2389671678 date "2014-01-01" @default.
- W2389671678 modified "2023-09-23" @default.
- W2389671678 title "Clinical application of chorionic villi karyotype analysis after abnormal first-trimester ultrasonographic findings" @default.
- W2389671678 hasPublicationYear "2014" @default.
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