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- W2389675093 abstract "Objective To investigate the role of transforming growth factor-β_1 (TGF-β_1) in the pathogenesis of the mouse model of sclerotic skin and to correlation analyze the content of collagen type I (COL-I ), III(COL-III) and TGF-β_1.Methods The Content of TGF-β_1 and collagen type I and III in the skin lesions from 7 mouse models of sclerotic skin ,and skin from 7 normal controls were detected by immunohistochemical method.Results A higher content of TGF-β_1 and collagen type I, III in the skin lesions of the mouse model of scleroderma were seen,compared with those in controls (P0.001) ,and The direct correlation between the content of TGF-β_1 and the content of collagen type I in the the mouse model of sclerotic skin were found(P0.05).Conclusion TGF-β_1 is produce intensely in the skin lesions of the mouse model of sclerotic skin,There are direct correlation between the content of TGF-β_1 and the content of collagen type I in the skin lesions of the mouse model of scleroderma. which implies that it may be involved in the pathogenesis of the mouse model of sclerotic skin and may be involved in the pathogenesis of scleroderma." @default.
- W2389675093 created "2016-06-24" @default.
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- W2389675093 date "2005-01-01" @default.
- W2389675093 modified "2023-09-22" @default.
- W2389675093 title "The Content And Correlation of Transforming Growth Factor-β_1 and Collagen Type I , III in the Mouse Model of Sclerotic Skin" @default.
- W2389675093 hasPublicationYear "2005" @default.
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