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- W2389679978 abstract "Objective To study the relationship between CD14 gene promoter-159C/T,-260C/T polymorphism and ischemic stroke,and to analyse its relation with lipoprotein in plasma.Methods Polymerase chain reaction-restriction fragment length polymorphism was used for the detection of CD14 genotypes in 132 patients with ischemic stroke and 145 healthy controls.The plasma lipid and lipoprotein levels were measured by routine method.Results Plasma total cholesterol,triglyceride and low density lipoprotein-cholesterol of the patients with ischemic stroke were significantly higher than those of the controls(P0.05),The distribution of CD14 gene-159C/T polymorphism was significantly different between ischemic stroke group and control group(P0.05).The relative risk for ischemic stroke in the patients with C allele was 1.556 times of that in those with T allele(OR=1.556,95%CI:1.108-2.184).The level of plasma lipid in C allele carriers was significantly higher than that in non-carriers(P0.05).Conclusion CD14 gene-159C/T polymorphism is associated with ischemic stroke and C allele is an important genetic risk factor.CD14 gene polymorphism may affect occurrence of ischemic stroke through influencing plasma lipid and lipoprotein levels." @default.
- W2389679978 created "2016-06-24" @default.
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- W2389679978 date "2007-01-01" @default.
- W2389679978 modified "2023-09-23" @default.
- W2389679978 title "Study on relationship of polymorphism of the CD14 gene promoter to ischemic stroke and serum lipid levels" @default.
- W2389679978 hasPublicationYear "2007" @default.
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