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- W2389694733 abstract "Objective:To assess the effect of naoxintong jiaonang (NXTJN) on endothelial dilation function in patients with elderly isolated systolic hypertension (ISH) by high frequency ultrasound.Methods:Seventy patients of ISH were randomized to receive nifedipine sustained-release tablets(nifedipine group )or nifedipine sustained-release tablets combined with NXTJN(naoxintong group )for 12weeks. The baseline of biachial angiobore and changes of it at respone to nitroglycerin and reactive hyperaemia were assessed by high frequency ultrasound before and after treatment.Results:SBP and DBP were significantly reduced in both groups after 12 weeks treatment compared to basiline level (P0.01 or P0.05,respectively ). The magnitude of reduction in SBP and DBP were similar in two groups(P0.05,all). The levels of TC LDL-C decreased significantly (P0.01) after NXTJN treatment 12 weeks. While in nifedipine group ,the levels of TC、LDL-C were not significantly decreased (P0.05 all)after treatment. The brachial endothelial-dependent vasodilation during reactive hyperemia(flow-mediated dilation,FMD) was improved (P0.01) in naoxintong group ,it was better(P0.01) than that of nifedipine group. However,there were no significantly change of vasodilation in response to nitroglycerin(NMD) in both groups (P0.05). No severs adverse effect was found in treating with NXTJN.Conclusion:FMD was impaired in ISH patients,and NXTJN may improve impaired FMD which was speculated beneficial to ISH patients." @default.
- W2389694733 created "2016-06-24" @default.
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- W2389694733 date "2010-01-01" @default.
- W2389694733 modified "2023-09-25" @default.
- W2389694733 title "Assessment of Effect of Naoxintong Jiaonang on Endothelial Dilation Function in Patients with Elderly Isolated Systolic Hypertension Based Ultrasound" @default.
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