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- W2389697906 abstract "Objective To investigate the influences of ACE inhibitors benazapril on the expression of vascular endothelial growth factor(VEGF) in kidney in experimental type 2 diabetic rats.Methods Type 2 diabetes model was induced by long-term high-fat feeding accompanied with intraperitoneal injection of streptozotocin(STZ).The morphological changes of kidney tissue were detected by light and electron microscope.Glomerular VEGF mRNA expression and protein synthesis were observed by the reverse transcription polymerase chain reaction and immunohistochemical staining respectively.Results Both VEGF mRNA and VEGF protein were significantly higher in type 2 diabetic rats than that in control rats(P0.01).Moreover,the main features of the diabetic renal parenchyma were found in type 2 diabetic rats.The expressions of VEGF mRNA and VEGF protein were decreased after treatment with benazapril(P0.01).The renal damages were significantly reduced as well.Conclusion The down-regulation of expression of VEGF by benazapril may be contribute to delaying the pathogenesis of diabetic nephropathy." @default.
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- W2389697906 date "2009-01-01" @default.
- W2389697906 modified "2023-09-27" @default.
- W2389697906 title "Influences of ACE inhibitors on renal expression of vascular endothelial growth factor in experimental type 2 diabetic rats" @default.
- W2389697906 hasPublicationYear "2009" @default.
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